4-HO-DET or as it is formally known, 4-Hydroxy-N,N-diethyltryptamine is not so well-known the synthetic, psychedelic tryptamine chemical class. It produces psilocin-like psychedelic effects when administered. 4-HO-DET is a close structural and functional analog of psilocin (4-HO-DMT), the principal psychoactive component in magic mushrooms. It is notable for sharing many of its core features while retaining subtle variations in its duration, visual, cognitive and bodily effects.
This compound was first discovered in the late 1950s, during investigations into various psychedelic compounds that were structurally and chemically related to the principle active components from magic mushrooms, psilocybin (4-PO-DMT) and psilocin (4-HO-DMT). The substance was used together with its phosphoryloxy-analog 4-PO-DET in human clinical trials in the 1960s, so research away!