4-HO-MET (4-hydroxy-N-methyl-N-ethyltryptamine, metocin or methylcybin) is a lesser known psychedelic tryptamine. It is a structural and functional analog of psilocin, as well as the 4-hydroxy analog of MET.
Tryptamines share a core structure comprising a bicylic indole heterocycle attached at R3, to an amino group, via an ethyl side chain. 4-HO-MET is substituted at R4 of its indole heterocycle with a hydroxyl functional group OH−. It also contains a methyl group and an ethyl chain bound to the terminal amine RN of its tryptamine backbone (MET). 4-HO-MET is a 4-hydroxy analogue of 4-AcO-MET and the N-substituted ethyl homologue of 4-HO-DMT.