NSI-189 is a benzylphiperizine-aminiopyridine, nootropic and neurogenic research chemical originally created by Neuralstem, Inc. that was derived from pyrazine and nicotinamide. Research has shown that NSI-189 stimulates neurogenesis of human hippocampus-derived neural stem cells in vivo and vitro. In healthy adult mice, NSI-189 has been shown to improve the hippocampal volume by 20% and reverse behavioral signs and symptoms in mouse depression models, meaning that it could address depression. The hippocampus is responsible for spatial navigation, along with the consolidation of information from short-term memory to long-term memory.
The chemical entity stimulates new neuron growth in the hippocampus, which is an area of the brain that is believed to contribute to conditions such as post-traumatic stress disorder (PTSD), Alzheimer’s disease, and major depressive disorder (MDD).