Nifoxipam Research Chemical: Understanding its Pharmacology

Posted by in on August 10, 2016 . .

Nifoxipam research chemical belongs to the class of benzodiazepine chemical group and is a minor metabolite of flunitrazepam. Nifoxipam has tranquillising and sleep-prolonging effects on human body and has much lower toxicity as compared to flunitrazepam and lormetazepam.

  • IUPAC Name: 3-hydroxydesmethylflunitrazepam, DP 370
  • Molar Mass: 315.256 g/mol 
  • Formula: C15H10FN3O4

                                                                       Nifoxipam Research Chemical Formula

Chemistry of Nifoxipam

Nifoxipam contains a benzene ring fused to a diazepine ring. It is an active metabolite of flunitrazepam. The benzyl ring of nifoxipam is substituted at R7 with a nitro group - NO2-. A flourine substituted phenyl ring is bound to this structure at R5. Nifoxipam also contains a hydroxy (OH-) group at R3 and an oxygen group double bonded to R2 of its diazepine ring to form a ketone. 

Pharmacology

As we know, benzodiazepines produce a variety of effects by binding to the benzodiazepine receptor site. Nifoxipam magnifies the effects of the neurotransmitter gamma aminobutyric acid (GABA) on human body by acting on its receptors which are set within the brain. Its modulation results in the sedating of nifoxipam on the nervous system. The anticonvulsant properties of nifoxipam are due to its binding to voltage-dependent sodium channels.

Metabolisation of Nifoxipam

In a study titled “Identification of main human urinary metabolites of the designer nitrobenzodiazepines clonazolam, meclonazepam, and nifoxipam by nano-liquid chromatography-high-resolution mass spectrometry for drug testing purposes” was conducted to identify the finall metabbolites of the latest members of benzodiazepines class appearing on the NPS market. In the study it was found that nifoxipam was extensively metabolized and was mainly excreted as the acetamino metabolite and a glucuronic acid conjugate of the parent.

                                                                       Buy Online Research Chemical in Eurpoe

Potential Effects

Nifoxipam is of the benzodiazepine class which produces anxiolytic, hypnotic, muscle relaxant, anticonvulsant, depressant and amnesic effects. The cognitive effects of nifoxipam are described by many as one of intense sedation and decreased inhibition. The most prominent of these cognitive effects generally include anxiety suppression, thought deceleration, analysis suppression, euphoria, compulsive redosing and emotion suppression.

Conclusion

Nifoxipam has potential use for the short-term treatment of anxiety, insomnia, and the sedation of hospitalized patients. However, it is currently exclusively sold by online research chemical vendors for use as in scientific experiment and laboratory research. You can easily buy nifoxipam in online research chemical shop in Europe at 99.9% purity at low prices. Note: This research chemical is only available for in vitro research purpose and not for human consumption.

 

Last update: August 10, 2016