Amazing facts that you must know about Pyrazolam Research Chemical
Pyrazolam is a water soluble derivative of benzodiazepine. Its IUPAC name is 8-bromo-1-methyl-6-(pyridin-2-yl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine having molecular formula - C16H12BrN5 and molecular mass of 354.2 g/mol. It is used as a leading chemical for the purpose of research by educational institutions, laboratories and scientists. However, there are certain amazing facts related to Pyrazolam chemical that you must know as a member of research community.
1. It was developed by a team lead by Leo Sternbach at Hoffman-La Roche in the 1970s. It was subsequently “rediscovered” and then marketed as a research chemical in 2012.
2. It is used as an anxiolytic as primary studies have revealed that Pyrazolam is more selective for the α2 and α3 receptor subtypes than its most benzodiazepines counterparts. It also acts as a high-affinity GABA positive allosteric modulator.
3. A study by B. Moosmann and team has showed that Pyrazolam has no active metabolites and its elimination half-life is about 17 hours. This helps a lot of researchers to conduct their tests easily.
4. This chemical has structural similarities to alprazolam and bromazepam and is known to be 12 times stronger than diazepam – a drug used for treating insomnia, muscle spasms, panic attacks, alcohol withdrawal and other conditions.
5. Because of greater selectivity for receptors, Pyrazolam causes lower level of ataxia. The physiological effects of the drug on the human body are still to be discovered.
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