4-Fluoromethylphenidate (4F-MPH) is a stimulant drug that acts as a higher efficiency dopamine reuptake inhibitor than its close analogue methylphenidate. It was initially developed as a replacement for ethylphenidate. Anecdotal reports suggest that 4F-MPH is considerably more potent with fewer side effects.

IUPAC Name: Methyl 2-(4-fluorophenyl)-2-(piperidin-2-yl)acetate

Molecular Formula: C14H18FNO2

Molar Mass: 251.3 g/mol

4-Fluoromethylphenidate Research Chemical

                                                                                                        Structure of 4F-MPH

Higher Binding Potency

A study has found that the meta- and para-substituted compounds with electron-withdrawing substituents in the threo-isomers of methylphenidate have increased binding potency. Compounds containing fluorine, chlorine, bromine and methyl groups were reported to be more potent than methylphenidate. Since 4F-MPH has fluorine, it has higher binding potency as dopamine reuptake inhibitor. It was reported as having ED50 mg/kg of 0.26 and a relative potency of 3.33 to Methylphenidate.

4F-MPH can boost neurotransmitters

4F-MPH acts as a dopamine reuptake inhibitor (DRI), which means it effectively boosts the levels of dopamine neurotransmitters in the brain. It binds or blocks the transporter proteins that remove monoamines from the synaptic cleft, resulting in the accumulation of dopamine within the brain. This causes stimulating and euphoric effects.

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Potential Uses

Chemicals that act as DRIs are used in the treatment of attention-deficit hyperactivity disorder (ADHD) and narcolepsy for their psychostimulant effects. They are also sometimes used in the treatment of obesity and binge eating disorder for their appetite suppressant effects. They can be used as antidepressants in the treatment of mood disorders. However, due to their higher potency their usage as antidepressants is limited. Lack of dopamine reuptake due to continuous usage of 4F-MPH has been linked to increased susceptibility to addictive behavior.

Pharmacotherapeutic Uses

Previously stimulant drugs with DRI action have been used clinically include: amineptine, dexmethylphenidate, difemetorex,fencamfamine, medifoxamine, nomifensine, prolintane, and pyrovalerone. Though all these drugs have different modes of action, so the pharmacotherapeutic use of 4F-MPH and its mode of action is yet to be discovered by the scientific community. Since this stimulant drug acts as DRI it can serve as nicotine replacement in cases of smoking addiction and methadone replacement in the case of heroin addiction. 

Where to buy 4F-MPH for research purpose?

Researchers and scientists can buy 4F-MPH pellets from trusted online vendor for research chemicals in the EU or their local area. Remember to buy only high quality research chemicals with 99.9% purity in order to obtain good research results.